HLA-G POLYMORPHISMS
![ico-perche-fare-test-gine](https://www.personalgenomics.it/en/wp-content/uploads/sites/2/2021/04/ico-perche-fare-test-gine.png)
Why get tested?
Genetic testing of this variant is indicated: in both individuals of a couple in the case of repeated IVF treatment failures or idiopathic recurrent spontaneous abortions and in the patient in case of heterologous insemination, to identify a donor with the HLA- genotype G compatible.
![ico-cosa-vede-test-dna-gine](https://www.personalgenomics.it/en/wp-content/uploads/sites/2/2021/04/ico-cosa-vede-test-dna-gine.png)
What the test detects and what the polymorphysm causes
The test identifies the presence of an insertion / deletion of 14 base pairs in the 3 ‘untranslated region of the gene (3 UTR) which has been associated with the increased risk of spontaneous abortions.
![ico-come-svolge-test-gine](https://www.personalgenomics.it/en/wp-content/uploads/sites/2/2021/04/ico-come-svolge-test-gine.png)
![ico-come-svolge-test-orizz-gine](https://www.personalgenomics.it/en/wp-content/uploads/sites/2/2021/04/ico-come-svolge-test-orizz-gine.png)
How testing works
The genetic test consists in the execution of a blood sampling, in the extraction of the genomic DNA and in the genotyping of the insertion / deletion of 14 base pairs (rs16375) using the CE-IVD HLA-001 kit, based on the real-time qPCR technique.
![ico-tempi-refertazione-gine](https://www.personalgenomics.it/en/wp-content/uploads/sites/2/2021/04/ico-tempi-refertazione-gine.png)
Reporting time
Results in 8-10 working days.
![ico-sensibilita-specificita-gine](https://www.personalgenomics.it/en/wp-content/uploads/sites/2/2021/04/ico-sensibilita-specificita-gine.png)
Sensitivity and specificity
Analytical sensitivity and specificity > 99,9%.