Genetic testing of this variant is indicated: in both individuals of a couple in the case of repeated IVF treatment failures or idiopathic recurrent spontaneous abortions and in the patient in case of heterologous insemination, to identify a donor with the HLA- genotype G compatible.
What the test detects and what the polymorphysm causes
The test identifies the presence of an insertion / deletion of 14 base pairs in the 3 ‘untranslated region of the gene (3 UTR) which has been associated with the increased risk of spontaneous abortions.
How testing works
The genetic test consists in the execution of a blood sampling, in the extraction of the genomic DNA and in the genotyping of the insertion / deletion of 14 base pairs (rs16375) using the CE-IVD HLA-001 kit, based on the real-time qPCR technique.