RISK OF HEART ARRYTHMIA
Why get tested?
The pathologies that cause an increased arrhythmic risk represent a set of pathologies caused by structural and functional anomalies of the heart muscle, which have consequences on the functioning of the myocardium. The test is indicated for subjects who have had a case of SCD or cardiac disease in the family, and for young subjects (under 40 years of age) with idiopathic cardiac symptoms or with a suspected clinical picture due to QT or heart rhythm abnormalities.
What the test detects
The tests allow to identify, in the investigated genes, small sequence variants such as: single nucleotide changes, insertions and deletions of a few base pairs. The sequence variants in the identified genes can predispose to a limited functional capacity of the heart which manifests itself with different symptoms and complications, including serious ones, such as: atrial fibrillation, malignant ventricular arrhythmias and sudden death. About 50% of cardiac arrests occur in individuals with no known heart disease. However, numerous studies have shown a genetic predisposition and it has been shown that individuals with a family history of sudden cardiac death (SCD) have a 50% increased risk of developing SCD.
How testing works
The genetic test consists in performing a blood test, in the extraction of genomic DNA and in the analysis of the aforementioned variants using the CE-IVD Devyser Thrombophilia kit based on the multiplex PCR technique and separation of the fragments by capillary electrophoresis on an automatic sequencer.
Which pathologies are detected
Results in 45 working days.
Sensitivity and specificity
Sensitivity, specificity analytical accuracy > 99%.