Novel Genomic Patterns of Metabolic Remodeling in Acute Myeloid Leukemia

Novel Genomic Patterns of Metabolic Remodeling in Acute Myeloid LeukemiaMetabolic remodeling of cancer is controlled by metabolic enzymes having oncogenic or tumor suppressor functions, dysregulated metabolic pathways contribute to the pathogenesis of Acute Myeloid Leukemia. Autori: Giorgia Simonetti, Antonella Padella, Ítalo Faria do Valle, Gabriele Fontanarosa, Elisa Zago, Marianna Garonzi, Cristina Papayannidis, Maria Chiara Abbenante, Giovanni Marconi, Viviana Guadagnuolo, Maria Chiara Fontana, Samantha Bruno, Anna Ferrari, Elisa Zuffa, Eugenia Franchini,…

RNA Sequencing Reveals Novel and Rare Fusion Transcripts in Acute Myeloid Leukemia

RNA Sequencing Reveals Novel and Rare Fusion Transcripts in Acute Myeloid LeukemiaChromosomal rearrangements and fusion genes have a crucial diagnostic, prognostic and therapeutic role in Acute Myeloid Leukemia. Autori: Antonella Padella, Giorgia Simonetti, Giulia Paciello, Anna Ferrari, Elisa Zago, Carmen Baldazzi, Viviana Guadagnuolo, Cristina Papayannidis, Valentina Robustelli, Enrica Imbrogno, Nicoletta Testoni, Gerardo Musuraca, Simona Soverini, Massimo Delledonne, Ilaria Iacobucci, Clelia Tiziana Storlazzi, Elisa Ficarra and Giovanni Martinelli; Blood2015 126:3627. Acute Myeloid Leukemia (AML) is a highly heterogeneous…

Abstract 3957: Integrated molecular characterization of mast cell leukemia reveals recurrent inactivation of the SETD2 tumor suppressor gene

Abstract 3957: Integrated molecular characterization of mast cell leukemia reveals recurrent inactivation of the SETD2 tumor suppressor geneAmong the mutated genes detected in mast cells, SETD2 is different because two mutations inactivating both alleles of the gene were identified. Autori: Simona Soverini et al Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. Molecular…

European Society of Human Genetics (ESHG)

European Society of Human Genetics (ESHG)European Human Genetics Conference. La conferenza Europea di Genetica Umana si svolgerà quest’anno a Gothenburg (Svezia), il 15 – 18 giugno 2019. Verranno trattati tutti i temi delle più recenti tecniche diagnostiche di genetica molecolare. Il team di Personal Genomics sarà presente a tale convegno allo scopo di acquisire e…